Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11066425 | 0.89 | ADRB2 (0.39) | SLC18A3ADRB2ADRB1HTR1AOPRK1 | |
| Iodide SCHEMBL11073338 | 0.88 | ADRB2 (0.39) | ADRB2ADRB1HTR1AOPRK1DRD2 | |
| Iodide SCHEMBL11068714 | 0.87 | DRD4 (0.42) | ADRB2ADRB1HTR1AOPRK1DRD2 | |
| Hydrochloric Acid SCHEMBL11068651 | 0.85 | HTR1A (0.39) | ADRB2ADRB1HTR1AOPRK1DRD2 | |
| Iodide SCHEMBL11065747 | 0.83 | ADRB1 (0.54) | SLC18A3ADRB2ADRB1HTR1AOPRK1 | |
| Iodide SCHEMBL11067095 | 0.80 | MAOB (0.57) | DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL11060253 | 0.79 | SLC18A3 (0.42) | SLC18A3DRD2 | |
| Iodide SCHEMBL11070555 | 0.79 | APOBEC3A (0.43) | ADRB2ADRB1HTR1AOPRK1DRD2 | |
| SCHEMBL11073435 | 0.79 | HTR7 (0.48) | DRD2DRD4DRD3SCN1ASCN5A | |
| Hydrochloric Acid SCHEMBL11070539 | 0.78 | HTR7 (0.47) | DRD2DRD4DRD3SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |