Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11065038 | 0.83 | MAOB (0.48) | SLC18A3TRPV1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL11060253 | 0.82 | SLC18A3 (0.42) | SLC18A3CYP19A1CYP11B1CYP11B2TRPV1 | |
| Iodide SCHEMBL11065747 | 0.82 | ADRB1 (0.54) | SLC18A3KCNH2ADRB2ADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL11073701 | 0.73 | DRD2 (0.49) | MAOAMAOB | |
| Hydrochloric Acid SCHEMBL11070395 | 0.73 | SLC18A3 (0.46) | SLC18A3ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11069036 | 0.71 | SCN1A (0.52) | SLC18A3KCNH2HTR1ASCN1ASCN5A | |
| Iodide SCHEMBL11064087 | 0.71 | ADRB1 (0.51) | SLC18A3KCNH2ADRB2ADRB1HTR1A | |
| Iodide SCHEMBL11067528 | 0.71 | SLC18A3 (0.47) | SLC18A3TRPV1 | |
| Iodide SCHEMBL11067095 | 0.70 | MAOB (0.57) | MAOAMAOB | |
| Hydrochloric Acid SCHEMBL11073533 | 0.70 | DRD2 (0.44) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |