SCHEMBL11060388

SCHEMBL11060388

COc1ccc(COC(=O)C(=O)OOOC(C)(C)C)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
KMT2A Q03164 2/20 0.45
HTT P42858 2/20 0.43
NPC1 O15118 1/20 0.42
POLB P06746 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MMP9 P14780 2/20 0.42
MMP1 P03956 1/20 0.42
MMP2 P08253 1/20 0.41
MMP12 P39900 1/20 0.41
FFAR1 O14842 1/20 0.40
ATM Q13315 1/20 0.40
FABP7 O15540 1/20 0.40
FABP5 Q01469 1/20 0.40
P2RX4 Q99571 1/20 0.40
IDO1 P14902 1/20 0.40
AGXT P21549 1/20 0.40
MIF P14174 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29389485 0.84 ALDH1A1 (0.50) ALDH1A1KMT2AHTTNPC1RAB9A
SCHEMBL3758807 0.83 ALDH1A1 (0.60) ALDH1A1HTTNPC1POLBRAB9A
SCHEMBL11109286 0.82 ALDH1A1 (0.50) ALDH1A1KMT2AHTTNPC1POLB
SCHEMBL10884366 0.79 HTT (0.45) ALDH1A1KMT2AHTTNPC1POLB
SCHEMBL28711475 0.78 ALDH1A1 (0.59) ALDH1A1KMT2AHTTNPC1POLB
SCHEMBL1521953 0.77 LTA4H (0.58) ALDH1A1HTTNPC1POLBRAB9A
SCHEMBL8645685 0.77 ALDH1A1 (0.54) ALDH1A1KMT2AHTTNPC1POLB
SCHEMBL6158485 0.75 ALDH1A1 (0.62) ALDH1A1KMT2AHTTNPC1POLB
SCHEMBL6285277 0.75 HPGD (0.56) ALDH1A1KMT2AHTTPOLBSMN1; SMN2
SCHEMBL8641118 0.75 NPC1 (0.56) ALDH1A1HTTNPC1POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4455412-A LOW TEMPERATURE, VINYL CHLORIDE ICI AUSTRALIA LIMITED (AU) 1984-06-19 US disclosed