Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5127809 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| SCHEMBL564456 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| Hydrochloric Acid SCHEMBL31362231 | 0.74 | ALDH1A1 (0.54) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| SCHEMBL28256353 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| SCHEMBL4649848 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| Bromide SCHEMBL11066185 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| SCHEMBL28423034 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| Bromide SCHEMBL6122965 | 0.73 | KDM4E (0.56) | ALDH1A1KDM4ETDP1DNM1MEN1 | |
| SCHEMBL28021011 | 0.72 | ACHE (0.57) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL6624834 | 0.72 | ALDH1A1 (0.45) | ALDH1A1KDM4ETDP1DNM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446123-A | QUATERNARY AMMONIUM, PHOSPHONIUM, OR ARSONIUM HALIDE | HAHNEMANN UNIVERSITY (US) | 1984-05-01 | — | — | US | claimed |
| US-4446123-A | QUATERNARY AMMONIUM, PHOSPHONIUM, OR ARSONIUM HALIDE | HAHNEMANN UNIVERSITY (US) | 1984-05-01 | — | — | US | disclosed |