Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17948794 | 0.86 | LMNA (0.56) | TSHRNOTUML3MBTL1HTTALDH1A1 | |
| SCHEMBL25448081 | 0.84 | SMN1; SMN2 (0.53) | KMT2ATSHRHTTALDH1A1LMNA | |
| SCHEMBL12027639 | 0.82 | L3MBTL1 (0.56) | NPC1RAB9ATSHRNOTUML3MBTL1 | |
| SCHEMBL17948720 | 0.81 | L3MBTL1 (0.58) | NOTUML3MBTL1HTTALDH1A1MAPK1 | |
| SCHEMBL8384325 | 0.81 | GAA (0.44) | KMT2ANPC1RAB9ANOTUML3MBTL1 | |
| SCHEMBL7974160 | 0.80 | ALDH1A1 (0.45) | KMT2ATSHRHTTALDH1A1POLB | |
| SCHEMBL11513567 | 0.79 | HTT (0.57) | KMT2ATSHRL3MBTL1HTTLMNA | |
| SCHEMBL7286780 | 0.79 | L3MBTL1 (0.56) | KMT2ARAB9ATSHRL3MBTL1HTT | |
| SCHEMBL11128528 | 0.79 | EGFR (0.58) | KMT2ANPC1RAB9ANOTUML3MBTL1 | |
| SCHEMBL7101708 | 0.78 | NOTUM (0.44) | KMT2ANPC1RAB9ANOTUML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110575-A1 | 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters | WARNER-LAMBERT COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4452990-A | TREATMENT OF SENILITY, AMNESIA AND MOTIVATION | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4447435-A | HYPOTENSIVE AGENTS | THE BOOTS COMPANY PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| US-4442109-A | 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for treating hypertension | THE BOOTS COMPANY LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |