Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477119 | 0.80 | PTGES (1.00) | PTGESMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL11240834 | 0.76 | PTGES (0.90) | PTGESMAPTNPC1RAB9ATHRB | |
| SCHEMBL11079379 | 0.73 | KMT2A (0.56) | PTGESKMT2AMAPTMEN1NPC1 | |
| SCHEMBL11485827 | 0.71 | PTGES (0.79) | PTGESMAPTRAB9ALMNAGAA | |
| SCHEMBL11244831 | 0.70 | PTGES (0.80) | PTGESMAPTALDH1A1LMNAGAA | |
| SCHEMBL9343218 | 0.70 | KMT2A (0.52) | PTGESKMT2AMAPTMEN1RAB9A | |
| SCHEMBL9507671 | 0.69 | ALDH1A1 (0.50) | PTGESMAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL9507613 | 0.69 | ALDH1A1 (0.50) | PTGESMAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL9508460 | 0.69 | ALDH1A1 (0.50) | PTGESMAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL9508463 | 0.69 | ALDH1A1 (0.50) | PTGESMAPTNPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500533-A | 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis | ELI LILLY AND COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| EP-0130046-A1 | Pyrimidine derivatives | ELI LILLY AND COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |