Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073219 | 0.83 | KDM4E (0.37) | KDM4ESMN1; SMN2HPGDMERTKCYP1A2 | |
| SCHEMBL9378832 | 0.81 | ALDH1A1 (0.36) | EGLN1KDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL10706002 | 0.81 | ALDH1A1 (0.36) | EGLN1KDM4ESMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL11065514 | 0.73 | PKM (0.41) | KDM4EHPGDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11061056 | 0.70 | MAPT (0.40) | KDM4EHPGDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11073593 | 0.68 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2HPGDCYP1A2CYP3A4 | |
| SCHEMBL9381563 | 0.68 | ADORA2A (0.35) | KDM4ESMN1; SMN2ALDH1A1MAPK1MAPT | |
| SCHEMBL11146963 | 0.68 | PKM (0.47) | KDM4ESMN1; SMN2HPGDALDH1A1POLB | |
| SCHEMBL11070935 | 0.66 | ADORA2A (0.35) | KDM4EALDH1A1MAPK1MAPTTNK2 | |
| SCHEMBL10708265 | 0.66 | KDM4E (0.38) | KDM4ESMN1; SMN2HPGDMERTKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |