Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378832 | 0.84 | ALDH1A1 (0.36) | ALDH1A1HSD17B10HPGDEGLN1SMN1; SMN2 | |
| SCHEMBL10708265 | 0.81 | KDM4E (0.38) | ALDH1A1HSD17B10HPGDSMN1; SMN2KDM4E | |
| SCHEMBL11062890 | 0.81 | EGLN1 (0.36) | ALDH1A1HSD17B10HPGDEGLN1SMN1; SMN2 | |
| SCHEMBL11073593 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2KDM4EEGLN2 | |
| SCHEMBL9381563 | 0.70 | ADORA2A (0.35) | ALDH1A1SMN1; SMN2KDM4EEGLN2MAPK1 | |
| SCHEMBL15272037 | 0.69 | PIK3CD (0.46) | ALDH1A1HSD17B10HPGDPIK3CDSMN1; SMN2 | |
| SCHEMBL7436879 | 0.67 | PDE10A (0.52) | ALDH1A1HSD17B10HPGDSMN1; SMN2KDM4E | |
| SCHEMBL11070935 | 0.66 | ADORA2A (0.35) | ALDH1A1KDM4ETDP1USP2MAPK1 | |
| SCHEMBL9378347 | 0.65 | SRC (0.36) | ALDH1A1EGLN1SMN1; SMN2KDM4E | |
| SCHEMBL11064822 | 0.65 | MAPT (0.41) | ALDH1A1HSD17B10HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152841-B1 | 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazolo[1,5-c]pyrimidines | G.D. Searle & Co. (US) | 1988-07-27 | — | — | EP | disclosed |
| US-4562192-A | VASODILATORS, DIURETICS, AND HYPOOTENSIVE AGENTS | G. D. SEARLE & CO. (US) | 1985-12-31 | — | — | US | disclosed |
| EP-0152841-A1 | 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazolo[1,5-c]pyrimidines | G.D. Searle & Co. (US) | 1985-08-28 | — | — | EP | disclosed |