Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068615 | 0.86 | GLA (0.47) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11256783 | 0.81 | GPR35 (0.40) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11641819 | 0.79 | GPR35 (1.00) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11075982 | 0.78 | KDM4E (0.46) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11262250 | 0.76 | MAPT (0.35) | GPR35KDM4ETDP1HPGDKMT2A | |
| SCHEMBL11064032 | 0.74 | GPR35 (0.52) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11641176 | 0.70 | GPR35 (0.73) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11641180 | 0.69 | GPR35 (0.77) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11641173 | 0.69 | GPR35 (0.77) | GPR35PDE2APDE1APDE1BPDE1C | |
| SCHEMBL11070695 | 0.69 | ALDH1A1 (0.36) | GPR35KDM4ETDP1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476132-A | Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them | CIBA-GEIGY CORPORATION (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0062001-A2 | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use | CIBA-GEIGY AG (CH) | 1982-10-06 | — | — | EP | disclosed |