Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065105 | 0.91 | MEN1 (0.31) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11060720 | 0.82 | CYP3A4 (0.36) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11062623 | 0.80 | LMNA (0.37) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11061001 | 0.73 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL11058684 | 0.73 | LMNA (0.43) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11065726 | 0.71 | XDH (0.37) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11062429 | 0.69 | MAPT (0.38) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11061481 | 0.69 | PLAU (0.33) | MEN1KMT2ATSHR | |
| SCHEMBL11063674 | 0.68 | CYP3A4 (0.38) | LMNAMEN1KMT2ANR1I2CHRM2 | |
| SCHEMBL11061057 | 0.67 | MAP3K7 (0.37) | LMNAMEN1KMT2ANR1I2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |