Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065100 | 0.90 | MEN1 (0.35) | XDHMEN1KMT2A | |
| SCHEMBL11060716 | 0.81 | MEN1 (0.36) | XDHMEN1NR1I2LMNACHRM2 | |
| SCHEMBL11062622 | 0.79 | CDK1 (0.33) | XDHMEN1NR1I2LMNACHRM2 | |
| SCHEMBL11064903 | 0.75 | L3MBTL1 (0.37) | CYP3A4MAPTCDK1CCNB1CCNA2 | |
| SCHEMBL11060673 | 0.72 | MAPK1 (0.35) | XDHMEN1KMT2ACDK1CDK2 | |
| SCHEMBL11058678 | 0.72 | LMNA (0.39) | XDHMEN1NR1I2LMNACHRM2 | |
| SCHEMBL11062388 | 0.68 | — | — | |
| SCHEMBL11057358 | 0.68 | MAP3K7 (0.36) | LMNACYP3A4MAPTMAPK8 | |
| SCHEMBL15485980 | 0.68 | ALOX5 (0.41) | MEN1CYP3A4MAPTKMT2A | |
| SCHEMBL11062426 | 0.68 | MAPT (0.34) | XDHMEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |