Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959912 | 0.94 | MAPT (0.36) | MAPTGAAHTTALDH1A1L3MBTL1 | |
| SCHEMBL10956420 | 0.90 | MAPT (0.36) | MAPTGAAHSD17B10HTTAPLNR | |
| SCHEMBL11055924 | 0.87 | MAPK1 (0.38) | HSD17B10HTTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11063670 | 0.85 | CDC7 (0.34) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL11062434 | 0.81 | MAPT (0.36) | MAPTHTTAPLNRALDH1A1L3MBTL1 | |
| SCHEMBL11058765 | 0.80 | ADORA3 (0.34) | MAPTGAAHTTALDH1A1L3MBTL1 | |
| SCHEMBL11069400 | 0.80 | MAP3K7 (0.38) | MAPTGAAHTTAPLNRALDH1A1 | |
| SCHEMBL11061052 | 0.79 | MAPK1 (0.41) | GAAHSD17B10HTTALDH1A1HPGD | |
| SCHEMBL11058255 | 0.79 | GAA (0.31) | MAPTGAAALDH1A1LMNA | |
| SCHEMBL11058678 | 0.77 | LMNA (0.39) | MAPTGAAHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |