Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957823 | 0.89 | ALDH1A1 (0.37) | MAPTTDP1ALDH1A1HTTGAA | |
| SCHEMBL11058255 | 0.87 | GAA (0.31) | MAPTALDH1A1GAALMNA | |
| SCHEMBL11066089 | 0.80 | MAPT (0.36) | MAPTKDM4EALDH1A1HTTGAA | |
| SCHEMBL11065024 | 0.78 | LMNA (0.46) | TDP1ALDH1A1HTTKMT2ALMNA | |
| SCHEMBL11058744 | 0.76 | MEN1 (0.33) | MAPTALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL10959912 | 0.76 | MAPT (0.36) | MAPTKDM4EALDH1A1HTTGAA | |
| SCHEMBL11062612 | 0.75 | HTT (0.35) | MAPTTDP1ALDH1A1HTTGAA | |
| SCHEMBL11062388 | 0.72 | — | — | |
| SCHEMBL10956420 | 0.72 | MAPT (0.36) | MAPTTDP1ALDH1A1HTTGAA | |
| SCHEMBL11055958 | 0.71 | HTT (0.40) | MAPTKDM4ETDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |