SCHEMBL11066640

SCHEMBL11066640

O=C1CCc2ccc(OCCCN3CCC(c4ccccc4)CC3)cc2N1

nearest known ligand 0.74

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOA P21397 16/20 0.71
MAOB P27338 16/20 0.71
DRD2 P14416 3/20 0.67
HTR6 P50406 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11068783 0.99 MAOA (0.70) MAOAMAOBDRD2HTR6
SCHEMBL30964249 0.97 MAOA (0.75) MAOAMAOBDRD2HTR6
SCHEMBL11062872 0.92 KDM1A (0.66) MAOAMAOBDRD2
SCHEMBL11074474 0.90 MAOA (0.68) MAOAMAOBDRD2
SCHEMBL11066832 0.90 MAOA (0.68) MAOAMAOBDRD2
SCHEMBL11066861 0.89 DRD2 (0.69) MAOAMAOBDRD2HTR6
SCHEMBL11064535 0.89 MAOA (0.64) MAOAMAOBDRD2
SCHEMBL11063294 0.86 DRD2 (0.68) MAOAMAOBDRD2HTR6
SCHEMBL11073358 0.86 DRD2 (0.70) MAOAMAOBDRD2HTR6
SCHEMBL11071264 0.86 DRD2 (0.82) MAOAMAOBDRD2HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4482560-A Carbostyril derivatives, and antihistaminic agents containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-11-13 US claimed
US-4482560-A Carbostyril derivatives, and antihistaminic agents containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-11-13 US disclosed