Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068752 | 0.86 | PGK1 (0.40) | LMNASMN1; SMN2HTTRAB9ANR2F2 | |
| SCHEMBL11071310 | 0.84 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1MAPK1HDAC3 | |
| SCHEMBL11066638 | 0.78 | ALDH1A1 (0.44) | LMNASMN1; SMN2HTTALDH1A1TSHR | |
| SCHEMBL10909912 | 0.73 | PKM (0.39) | PKM | |
| SCHEMBL2058933 | 0.69 | PKM (0.46) | PKM | |
| SCHEMBL21603964 | 0.69 | PKM (0.37) | SMN1; SMN2HTTALDH1A1CACNA2D1MAPT | |
| SCHEMBL11068442 | 0.68 | PKM (0.36) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL12092541 | 0.67 | CHEK2 (0.49) | LMNASMN1; SMN2HTTRAB9ANR2F2 | |
| SCHEMBL28836687 | 0.63 | PKM (0.41) | PKM | |
| SCHEMBL10959564 | 0.62 | PGK1 (0.34) | PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | disclosed |