Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.66 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353037 | 0.79 | BRD4 (0.66) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8853797 | 0.79 | CREBBP (1.00) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9817819 | 0.78 | ALDH1A1 (1.00) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9629696 | 0.77 | CREBBP (0.71) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8853794 | 0.76 | BRD4 (0.65) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL4762702 | 0.74 | CREBBP (0.59) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL10353017 | 0.73 | BRD4 (0.54) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9629700 | 0.73 | BRD4 (0.57) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL14273765 | 0.73 | ALDH1A1 (0.64) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8853387 | 0.73 | BRD4 (0.61) | BRD4CREBBPALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4477464-A | Hetero-benzazepine derivatives and their pharmaceutical use | CIBA-GEIGY CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |