Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.59 |
| ▸ | BRD4 | O60885 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353037 | 0.74 | BRD4 (0.66) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL11069336 | 0.74 | BRD4 (0.66) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL8853797 | 0.74 | CREBBP (1.00) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL9817819 | 0.73 | ALDH1A1 (1.00) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL9629696 | 0.72 | CREBBP (0.71) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL8853794 | 0.71 | BRD4 (0.65) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL30583054 | 0.71 | HSD17B10 (0.59) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL9629698 | 0.70 | CREBBP (0.64) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL9602657 | 0.69 | SMN1; SMN2 (0.72) | CREBBPBRD4HSD17B10ALDH1A1TSHR | |
| SCHEMBL9287395 | 0.69 | BRD4 (0.57) | CREBBPBRD4HSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567520-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2008-10-15 | — | — | EP | claimed |