Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368744 | 0.73 | MAPT (0.47) | MAPTXBP1LMNAKDM4ENPC1 | |
| SCHEMBL14280080 | 0.71 | MAPT (0.51) | MAPTXBP1LMNAKDM4ENPC1 | |
| SCHEMBL23686773 | 0.70 | GPR3 (0.46) | ACHEBCHEGPR3HTR2AMAPT | |
| SCHEMBL13327250 | 0.69 | GPR3 (0.44) | ACHEBCHEGPR3HTR2AMAPT | |
| SCHEMBL9016831 | 0.68 | MAPT (0.56) | MAPTXBP1LMNAKDM4ENPC1 | |
| SCHEMBL1996543 | 0.67 | HTR2A (0.54) | ACHEBCHEGPR3HTR2ACHRM2 | |
| SCHEMBL8369184 | 0.67 | MAPT (0.44) | ACHEGPR3HTR2AMAPTXBP1 | |
| SCHEMBL633764 | 0.66 | HTR2A (0.58) | ACHEBCHEGPR3HTR2ACHRM2 | |
| SCHEMBL10447563 | 0.65 | ACHE (0.46) | ACHEBCHEGPR3HTR2ACHRM2 | |
| SCHEMBL313685 | 0.65 | ACHE (0.55) | ACHEBCHEGPR3HTR2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153667-B2 | ATPase inhibitors; Substituted fluorene or benzenerings joined to an alkylene through a sulfone or sulfoxide linkage; without excessive toxicity, irritation, allergic response etc.; sleep dioredrs like excessive sleepiness; Parkinson's disease; Alzheimer's disease; ADD; ADHA; depression, fatigue | CEPHALON, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-20080070956-A1 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives | CEPHALON, INC. (US) | 2008-03-20 | — | — | US | disclosed |
| US-7314875-B2 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives | CEPHALON, INC. (US) | 2008-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070956-A1 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives | PAH, TYR, AHR | ACHE 800/4885BCHE 1692/4885GPR3 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.