Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Triethyl Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | PPARD known ✓ | Q03181 | 2/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.93 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethyl Phosphate SCHEMBL28070003 | 0.97 | TSHR (0.87) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL1332591 | 0.96 | TSHR (1.00) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL21887 | 0.96 | TSHR (1.00) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL28023664 | 0.96 | TSHR (1.00) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL27822049 | 0.96 | TSHR (1.00) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL23092283 | 0.93 | TSHR (0.93) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL1332661 | 0.93 | TSHR (0.93) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL30712957 | 0.93 | TSHR (0.93) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL29254609 | 0.93 | TSHR (0.93) | TSHRTP53TDP1CYP3A4ACHE | |
| Triethyl Phosphate SCHEMBL28548922 | 0.93 | TSHR (0.93) | TSHRTP53TDP1CYP3A4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014006228-A1 | VASCULAR BED-SPECIFIC ENDOTHELIAL CELLS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2014-01-09 | — | — | WO | disclosed |
| EP-0041587-B1 | CATALYST COMPOSITIONS, PRODUCTION THEREOF, AND USE IN PRODUCTION OF OXYGENATED ORGANIC COMPOUNDS | THE STANDARD OIL COMPANY (US) | 1984-11-14 | — | — | EP | disclosed |
| US-4451407-A | CATALYST OF COBALT AND/OR RUTHENIUM CARBONYL AND AN N-HETEROCYCLIC N-OXIDE; CATALYST SELECTIVITY | THE STANDARD OIL COMPANY (US) | 1984-05-29 | — | — | US | disclosed |
| US-4344866-A | COBALT CARBONYL, RUTHENIUM OXIDE, SULFUR AND PHOSPHORUS OXIDE | STANDARD OIL COMPANY (US) | 1982-08-17 | — | — | US | disclosed |
| US-4331612-A | CATALYSTS COMPRISING COBALT CARBONYL AND A PROMOTER LIGAND OF A HETEROCYCLIC NITROGEN OXIDE; ACRYLONITRILE | STANDARD OIL COMPANY (US) | 1982-05-25 | — | — | US | disclosed |
| US-4313893-A | COBALT CARBONYL OR BUTHENIUM CARBONYL CATALYST WITH PHOSPHORUS OXIDE OR SULFUR OXIDE PROMOTER LIGAND | STANDARD OIL COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| EP-0041587-A1 | Catalyst compositions, production thereof, and use in production of oxygenated organic compounds | THE STANDARD OIL COMPANY (US) | 1981-12-16 | — | — | EP | disclosed |
| US-4238357-A | CATALYST COMPRISING COBALT OR RUTHENIUM CARBONYL AND AN N-OXYGEN-SUBSTITUTED NITROGEN HETEROCYCLIC PROMOTER LIGAND | STANDARD OIL COMPANY (US) | 1980-12-09 | — | — | US | disclosed |