Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10986756 | 0.99 | DRD2 (0.49) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10905719 | 0.80 | DRD2 (0.52) | DRD2HTR1AHTR2A | |
| SCHEMBL11228025 | 0.77 | SIGMAR1 (0.59) | TSHR | |
| SCHEMBL9377459 | 0.77 | DRD2 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10986491 | 0.77 | DRD2 (0.67) | DRD2DRD4DRD3GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL7318328 | 0.76 | DRD2 (0.53) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10366616 | 0.76 | DRD2 (0.56) | DRD2DRD4DRD3GRM2HTR1A | |
| Bromide SCHEMBL10991850 | 0.74 | DRD2 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL11784439 | 0.74 | CHRNA7 (0.56) | DRD2HTR2A | |
| SCHEMBL11249894 | 0.74 | HTR7 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | claimed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | claimed |