Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10898652 | 0.90 | HTR2A (0.50) | HTR2A | |
| SCHEMBL10896514 | 0.90 | DRD2 (0.62) | DRD2 | |
| SCHEMBL11244508 | 0.90 | HTR2A (0.52) | HTR2A | |
| SCHEMBL11249894 | 0.90 | HTR7 (0.46) | HTR7 | |
| SCHEMBL11249964 | 0.88 | HTR1A (0.51) | HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL10896178 | 0.87 | HTR1A (0.50) | HTR2AHTR1A | |
| SCHEMBL11245921 | 0.87 | — | — | |
| SCHEMBL11249933 | 0.81 | HTR1A (0.62) | HTR1A | |
| SCHEMBL85060 | 0.80 | DRD2 (0.61) | DRD2HTR2AHTR1AHTR7KCNH2 | |
| SCHEMBL11073263 | 0.80 | DRD2 (0.50) | DRD2HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079564-B1 | 3-(1-SUBSTITUTED-4-PIPERIDYL)-1,2-BENZISOXAZOLES, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-03-19 | — | — | EP | disclosed |
| EP-0079564-A1 | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles, a process for the preparation thereof, a pharmaceutical composition comprising the same, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4352811-A | NEUROLEPTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-10-05 | — | — | US | disclosed |