Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886127 | 0.88 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B10TDP1CHRM2 | |
| SCHEMBL1886128 | 0.88 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B10TDP1CHRM2 | |
| Methyl Alcohol SCHEMBL8398762 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10TDP1CHRM2 | |
| Dimethyl Sulfoxide SCHEMBL176884 | 0.83 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10TDP1LMNA | |
| Acetonitrile SCHEMBL9387131 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10TDP1CHRM2 | |
| Dimethyl Sulfoxide SCHEMBL8608347 | 0.77 | — | — | |
| Dimethyl Sulfoxide SCHEMBL1128520 | 0.77 | — | — | |
| Dimethyl Sulfoxide SCHEMBL898784 | 0.76 | CA12 (0.31) | TSHRHSD17B10CHRM2CHRM4CHRM5 | |
| Dimethylformamide SCHEMBL8835272 | 0.76 | ALDH1A1 (0.43) | ALDH1A1TSHRHSD17B10TDP1CHRM2 | |
| Dimethyl Sulfoxide SCHEMBL9877938 | 0.75 | PPIP5K2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4473502-A | Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid | MERCK & CO., INC. (US) | 1984-09-25 | — | — | US | disclosed |
| US-4467107-A | INTERMEDIATES FOR THIENAMYCIN | MERCK & CO., INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4349687-A | Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid | MERCK & CO., INC. (US) | 1982-09-14 | — | — | US | disclosed |