Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIP5K2 | O43314 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905925 | 0.90 | PPIP5K2 (0.35) | PPIP5K2 | |
| Dimethyl Sulfoxide SCHEMBL177271 | 0.85 | — | — | |
| Dimethyl Sulfoxide SCHEMBL8483068 | 0.85 | — | — | |
| SCHEMBL11564478 | 0.80 | ALDH1A1 (0.36) | PPIP5K2 | |
| Dimethyl Sulfoxide SCHEMBL11074140 | 0.75 | ALDH1A1 (0.46) | — | |
| Dimethyl Sulfoxide SCHEMBL6082696 | 0.75 | ALDH1A1 (0.39) | — | |
| SCHEMBL16389943 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL1432241 | 0.74 | OPRK1 (0.35) | — | |
| SCHEMBL8048547 | 0.74 | TSHR (0.39) | — | |
| SCHEMBL4485811 | 0.72 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106467563-B | The synthetic method and its midbody compound of chondroitin sulfate tetrose | 北京大学 | 2019-08-06 | — | — | CN | claimed |
| CN-106467563-A | The synthetic method of chondroitin sulfate tetrose and its midbody compound | 北京大学 | 2017-03-01 | — | — | CN | claimed |
| US-4992542-A | Thienamycin antibiotics | MERCK & CO., INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0071908-B1 | 1-, AND 1,1-DISUBSTITUTED-6-SUBSTITUTED-2-CARBAMIMIDOYL-1-CARBADETHIAPEN-2-EM-3-CARBOXYLIC ACIDS, A PROCESS FOR PREPARING AND AN ANTIBIOTIC COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1989-09-27 | — | — | EP | disclosed |
| EP-0275002-A1 | Process for the production of 7-oxo-4-thia-1-aza-bicyclo [3.2.0] hept-2-ene derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-20 | — | — | EP | disclosed |
| US-4739048-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1988-04-19 | — | — | US | disclosed |
| US-4736025-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0257419-A1 | Process for the preparation of antibacterial 7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0230792-A1 | Process for making chiral 1 beta-methyl-carbapenem intermediates | MERCK & CO. INC. (US) | 1987-08-05 | — | — | EP | disclosed |
| EP-0050334-B1 | 2-CARBAMIMIDOYL-6-SUBSTITUTED-1-CARBADETHIAPEN-2-EM-3-CARBOXYLIC ACIDS, A PROCESS FOR PREPARING AND AN ANTIBIOTIC COMPOSITION COMPRISING THE SAME | MERCK & CO. INC. (US) | 1987-06-10 | — | — | EP | disclosed |
| US-4617152-A | β-lactams containing an α-exocyclic double bond | MERCK & CO., INC. (US) | 1986-10-14 | — | — | US | disclosed |
| US-4290947-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4273709-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1981-06-16 | — | — | US | disclosed |
| EP-0030031-A2 | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing the same, an antibiotic pharmaceutical composition comprising the same, intermediates useful in a synthesis of that kind and processes for preparing intermediates suitable for the synthesis of that kind | MERCK & CO. INC. (US) | 1981-06-10 | — | — | EP | disclosed |
| EP-0026817-A1 | Preparation of azetidin-2-ones suitable for the synthesis of thienamycin and azetidin-2-ones useful in a synthesis of that kind | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |
| EP-0026816-A1 | Intermediates for the preparation of thienamycin and process for preparing intermediates | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |
| US-4262010-A | THIENAMYCIN-RELATED ANTIBIOTICS | MERCK & CO., INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0018594-A2 | Process for the preparation of 3-(1-hydroxyethyl)-azetidinones | MERCK & CO. INC. (US) | 1980-11-12 | — | — | EP | disclosed |
| EP-0017992-A1 | 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates | MERCK & CO. INC. (US) | 1980-10-29 | — | — | EP | disclosed |
| EP-0007973-A1 | Process for the preparation of thienamycin and intermediates | MERCK & CO. INC. (US) | 1980-02-20 | — | — | EP | disclosed |