Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668348 | 0.89 | ACE (0.48) | ACE | |
| SCHEMBL10668345 | 0.89 | ACE (0.48) | ACE | |
| SCHEMBL10667341 | 0.86 | TDP1 (0.43) | ACEITGB3ITGA2BTDP1ATM | |
| SCHEMBL10663870 | 0.85 | ITGB3 (0.41) | ITGB3ITGA2BMEN1KMT2ACXCR3 | |
| SCHEMBL11036872 | 0.84 | CTSK (0.43) | ACEITGB3ITGA2BCXCR3SIRT5 | |
| SCHEMBL31553483 | 0.77 | TDP1 (0.48) | ITGB3ITGA2BTDP1ATMPOLB | |
| SCHEMBL31553482 | 0.75 | TDP1 (0.50) | TDP1ATMPOLBNPSR1MEN1 | |
| SCHEMBL11394267 | 0.74 | POLB (0.33) | ACEITGB3ITGA2BTDP1ATM | |
| SCHEMBL31488230 | 0.72 | TDP1 (0.45) | TDP1ATMPOLBNPSR1MEN1 | |
| SCHEMBL30665183 | 0.72 | TDP1 (0.48) | TDP1ATMPOLBNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036713-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | UNIVERSITY OF MIAMI (US) | 1984-01-18 | — | — | EP | disclosed |