Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015826 | 0.71 | RAD52 (0.35) | ALDH1A1TSHRLMNARAD52MAPT | |
| SCHEMBL21351967 | 0.71 | ALDH1A1 (0.36) | ALDH1A1TSHRLMNARAD52MAPT | |
| SCHEMBL15090546 | 0.70 | KDM4E (0.43) | ALDH1A1TSHRLMNAMAPTKMT2A | |
| SCHEMBL15090763 | 0.67 | KDM4E (0.46) | ALDH1A1TSHRLMNAKMT2ANUDT1 | |
| SCHEMBL14833892 | 0.66 | KEAP1 (0.44) | HSD17B10RAD52PGR | |
| SCHEMBL15284311 | 0.65 | ALDH1A1 (0.54) | ALDH1A1TSHRLMNAHSD17B10MAPT | |
| SCHEMBL8655277 | 0.64 | ALOX5 (0.49) | ALDH1A1RAD52CHRM5CHRM1SMN1; SMN2 | |
| SCHEMBL16236934 | 0.64 | KDM4E (0.43) | ALDH1A1TSHRLMNAKMT2ANUDT1 | |
| P-Xylene SCHEMBL11399447 | 0.63 | LMNA (0.54) | ALDH1A1TSHRLMNAHSD17B10RAD52 | |
| SCHEMBL21569583 | 0.63 | GPR84 (0.38) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114632-A1 | 5-(4-Vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3H-pyrrolo-(1,2-A)-pyrrole-1-carboxylic acids and derivatives thereof | SYNTEX (U.S.A.) INC. (US) | 1984-08-01 | — | — | EP | disclosed |
| EP-0041711-A1 | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo(1,2-a)-pyrrole-1-carboxylic acids and derivatives thereof, process for their production and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1981-12-16 | — | — | EP | disclosed |