Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001954 | 0.83 | KDM4E (0.64) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL11085707 | 0.73 | S100A4 (0.45) | DRD2DRD5DRD3KDM4ES100A4 | |
| SCHEMBL30073106 | 0.73 | KDM4E (0.72) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL30073110 | 0.73 | KDM4E (0.72) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL9376682 | 0.73 | DRD2 (0.60) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL9377426 | 0.73 | ADAM17 (0.47) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL5240140 | 0.72 | DRD3 (0.58) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL9375600 | 0.72 | ADAM17 (0.46) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL9376168 | 0.72 | HTR7 (0.61) | DRD2DRD5DRD3KDM4EALOX15 | |
| SCHEMBL9375915 | 0.72 | HTR7 (0.61) | DRD2DRD5DRD3KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434100-A | TRANQUILIZING, ANTICONVULSANTS, ANXIOLYTIC | CIBA-GEIGY CORPORATION (US) | 1984-02-28 | — | — | US | disclosed |
| US-4356176-A | TRANQUILIZERS, ANTICONVULSANT | CIBA-GEIGY CORPORATION (US) | 1982-10-26 | — | — | US | disclosed |
| US-4315926-A | ANXIOLYTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-02-16 | — | — | US | disclosed |