Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083016 | 0.86 | L3MBTL1 (0.50) | LMNAMEN1KMT2AADORA1KDM4E | |
| SCHEMBL11484356 | 0.85 | MEN1 (0.49) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11245668 | 0.83 | LMNA (0.43) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11486422 | 0.81 | LMNA (0.45) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL6221158 | 0.80 | ADORA1 (0.49) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11161764 | 0.77 | MEN1 (0.42) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11076414 | 0.77 | ADORA1 (0.45) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11075122 | 0.77 | ADORA1 (0.45) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11167563 | 0.77 | MEN1 (0.41) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11158118 | 0.76 | EEF2K (0.48) | LMNAMEN1KMT2AABCC4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060012-B1 | 4-HALO-1,8-NAPHTHYRIDINE DERIVATIVES USEFUL AS INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-29 | — | — | EP | claimed |
| US-4350817-A | 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | claimed |
| EP-0060012-A1 | 4-Halo-1,8-naphthyridine derivatives useful as intermediates and processes for their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-15 | — | — | EP | claimed |
| EP-0018735-A1 | 1,8-Naphthyridine derivatives, their preparation, pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-12 | — | — | EP | claimed |
| US-4215123-A | Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |