Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11167153 | 0.88 | KDM4E (0.47) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11075024 | 0.88 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11083526 | 0.88 | LMNA (0.52) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11083105 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL11080468 | 0.86 | LMNA (0.48) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11486236 | 0.85 | KDM4E (0.59) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL11485860 | 0.84 | KDM4E (0.46) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11164219 | 0.82 | KDM4E (0.45) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11161757 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL11167142 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060012-B1 | 4-HALO-1,8-NAPHTHYRIDINE DERIVATIVES USEFUL AS INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-29 | — | — | EP | disclosed |
| EP-0018735-B1 | 1,8-NAPHTHYRIDINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-07-27 | — | — | EP | disclosed |
| US-4350817-A | 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0060012-A1 | 4-Halo-1,8-naphthyridine derivatives useful as intermediates and processes for their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4324893-A | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-04-13 | — | — | US | disclosed |
| EP-0018735-A1 | 1,8-Naphthyridine derivatives, their preparation, pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-12 | — | — | EP | disclosed |
| US-4215123-A | Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |