Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234096 | 0.84 | KMT2A (0.44) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11080468 | 0.83 | LMNA (0.48) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL11075024 | 0.82 | L3MBTL1 (0.49) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11080007 | 0.78 | FEN1 (0.51) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12291846 | 0.71 | EGLN1 (0.58) | LMNAMEN1KMT2AABCC4PKM | |
| SCHEMBL29524438 | 0.71 | ALDH1A1 (0.56) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10672789 | 0.71 | ALDH1A1 (0.56) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11083016 | 0.70 | L3MBTL1 (0.50) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30080112 | 0.70 | UBE2N (0.35) | CNR1CNR2EGFRPTGDR2 | |
| SCHEMBL8141322 | 0.70 | ALDH1A1 (0.61) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4350817-A | 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| US-4324893-A | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-04-13 | — | — | US | disclosed |