Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080546 | 0.92 | YAP1 (0.49) | YAP1LMNAITGB3ITGA2BGHSR | |
| SCHEMBL11084132 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BKMT2APLA2G10PLA2G5 | |
| SCHEMBL11084218 | 0.84 | ITGB3 (0.43) | ITGB3ITGA2BMEN1KMT2APLA2G10 | |
| SCHEMBL11077466 | 0.82 | PLA2G10 (0.52) | ITGB3ITGA2BPLA2G10PLA2G5NR1H2 | |
| SCHEMBL11078135 | 0.81 | LMNA (0.47) | YAP1LMNAGHSRMEN1KMT2A | |
| SCHEMBL6936067 | 0.77 | PLA2G10 (0.54) | MEN1KMT2APLA2G10PLA2G5NR1H2 | |
| SCHEMBL7650079 | 0.76 | PLA2G10 (0.41) | ITGB3ITGA2BMEN1KMT2APLA2G10 | |
| SCHEMBL5043388 | 0.75 | ABHD6 (0.43) | YAP1GHSRPLA2G10PLA2G5NR1H2 | |
| SCHEMBL11088457 | 0.75 | HTT (0.40) | YAP1ITGB3ITGA2BGHSRMEN1 | |
| SCHEMBL11078872 | 0.75 | CCR3 (0.44) | ITGB3ITGA2BMEN1KMT2APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483988-A | Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones | RICHARDSON MERRELL INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4435571-A | 5-(Substituted benzyl)-6-oxo-2-piperazine carboxylic acids and esters | RICHARDSON MERRELL INC. (US) | 1984-03-06 | — | — | US | disclosed |
| US-4341698-A | Enkaphalin derivatives | RICHARDSON-MERRELL INC. (US) | 1982-07-27 | — | — | US | disclosed |