Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729565 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL11422536 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL11422534 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL1096806 | 0.75 | KDM4E (0.49) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL7518004 | 0.74 | ESR1 (0.39) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL3133065 | 0.73 | CDK2 (0.46) | ALDH1A1KDM4ESMN1; SMN2HSD17B10CYP3A4 | |
| SCHEMBL29904571 | 0.73 | CDK2 (0.46) | ALDH1A1KDM4ESMN1; SMN2HSD17B10CYP3A4 | |
| SCHEMBL9165551 | 0.73 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL1097594 | 0.72 | AURKA (0.34) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL5368108 | 0.70 | KDM4E (0.57) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153410-B2 | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules | FOX CHASE CANCER CENTER (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | FOX CHASE CANCER CENTER (US) | 2009-02-19 | — | — | US | disclosed |
| US-4265633-A | Process for the manufacture of vat dyes | CIBA-GEIGY AG (CH) | 1981-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048324-A1 | ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES | BMP2, BMP1, MYOF | ALDH1A1 4738/4885KDM4E 3883/4885LMNA 3063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.