Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 8/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455335 | 0.89 | EPHX1 (0.46) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL8562608 | 0.84 | GAA (0.39) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2912153 | 0.79 | ACHE (0.48) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL9842283 | 0.78 | ACHE (0.41) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL8134500 | 0.74 | — | — | |
| SCHEMBL7822178 | 0.74 | MAPT (0.39) | SMN1; SMN2ALDH1A1MAPK1KDM4EMEN1 | |
| SCHEMBL27393398 | 0.73 | ACHE (0.43) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL21077348 | 0.73 | ACHE (0.43) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL11280768 | 0.72 | MAPK1 (0.36) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL11403086 | 0.72 | MAPK1 (0.36) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |