Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332981 | 0.86 | MAPK1 (0.35) | MAPK1PDE10AHSD11B1HDAC4AOC3 | |
| SCHEMBL14734253 | 0.84 | HTR3A (0.41) | MAPK1HRH4NPC1RAB9A | |
| SCHEMBL29138593 | 0.83 | ESR2 (0.37) | MAPK1HSD11B1AOC3 | |
| Hydrochloric Acid SCHEMBL30758569 | 0.83 | HTR3A (0.40) | MAPK1HRH4NPC1RAB9A | |
| SCHEMBL21037756 | 0.81 | DRD4 (0.41) | HSD11B1AOC3 | |
| SCHEMBL1739269 | 0.78 | CHRNB2 (0.39) | HSD11B1 | |
| SCHEMBL30686980 | 0.77 | HSD11B1 (0.33) | MAPK1HSD11B1 | |
| SCHEMBL29138584 | 0.77 | MAPK1 (0.37) | MAPK1PDE10AHSD11B1 | |
| SCHEMBL18965272 | 0.77 | PARP1 (0.39) | HSD11B1 | |
| Hydrochloric Acid SCHEMBL29277042 | 0.75 | HTR3A (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474958-A | 2-Alkyl-5-halopyrimidines | THE DOW CHEMICAL COMPANY (US) | 1984-10-02 | — | — | US | claimed |
| EP-0097451-A1 | 2-Alkyl-5-pyrimidines | THE DOW CHEMICAL COMPANY (US) | 1984-01-04 | — | — | EP | claimed |
| US-4474958-A | 2-Alkyl-5-halopyrimidines | THE DOW CHEMICAL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0097451-A1 | 2-Alkyl-5-pyrimidines | THE DOW CHEMICAL COMPANY (US) | 1984-01-04 | — | — | EP | disclosed |