Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30758569 | 0.98 | HTR3A (0.40) | HTR3AHRH3HRH4SLC18A3SIGMAR1 | |
| SCHEMBL2636802 | 0.88 | HTR3A (0.52) | HTR3A | |
| Hydrochloric Acid SCHEMBL29277042 | 0.86 | HTR3A (0.50) | HTR3A | |
| SCHEMBL11086191 | 0.84 | MAPK1 (0.39) | HRH4NPC1RAB9AMAPK1 | |
| SCHEMBL6782585 | 0.82 | HTR3A (0.46) | HTR3ANPC1RAB9AMAPK1KMT2A | |
| SCHEMBL31736812 | 0.81 | SLC18A3 (0.48) | HRH3HRH4SLC18A3SIGMAR1USP7 | |
| SCHEMBL25330171 | 0.79 | USP7 (0.46) | HRH3HRH4SLC18A3SIGMAR1USP7 | |
| SCHEMBL12068365 | 0.79 | HTR2C (0.43) | HRH3SLC18A3SIGMAR1CDK7CDK9 | |
| SCHEMBL31438848 | 0.79 | HRH4 (0.42) | HRH3HRH4SLC18A3SIGMAR1CDK9 | |
| SCHEMBL14243072 | 0.79 | HRH3 (0.41) | HRH3SLC18A3SIGMAR1USP7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025245178-A1 | PAK4, CSTF2, OR CSTF2T PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | INNOVO THERAPEUTICS, INC. (US) | 2025-11-27 | — | — | WO | disclosed |
| CN-116925099-B | Preparation method and application of chiral dihydrothienopyrimidine sulfoxide and 2-and 4-substituted compound thereof | 厦门大学 | 2025-06-03 | — | — | CN | disclosed |
| WO-2025092985-A1 | PHOSPHODIESTERASE 4B INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 合肥医工医药股份有限公司 | 2025-05-08 | — | — | WO | disclosed |
| CN-119930644-A | Phosphodiesterase 4B inhibitor and preparation method and application thereof | 合肥医工医药股份有限公司 | 2025-05-06 | — | — | CN | disclosed |
| WO-2025020462-A1 | PREPARATION METHOD FOR CHIRAL DIHYDROTHIENOPYRIMIDINE SULFOXIDE AND USE THEREOF, AND 2- AND 4-SUBSTITUTED COMPOUND OF CHIRAL DIHYDROTHIENOPYRIMIDINE SULFOXIDE | 厦门大学 | 2025-01-30 | — | — | WO | disclosed |
| WO-2023241684-A1 | PDE4B INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-21 | — | — | WO | disclosed |
| WO-2023241683-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND ACTING AS PDE4B INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-21 | — | — | WO | disclosed |
| CN-117247394-A | Nitrogen-containing heterocycles as PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-117247395-A | PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-116925099-A | Preparation method and application of chiral dihydrothienopyrimidine sulfoxide and 2-and 4-substituted compound thereof | 厦门大学 | 2023-10-24 | — | — | CN | disclosed |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-8741892-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-03 | — | — | US | disclosed |
| WO-2013083591-A1 | SUBSTITUTED PYRAZOLES AS MGLU5 RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | WO | disclosed |
| US-20130143870-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-06 | — | — | US | disclosed |
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| WO-2013026797-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, SQOR, TST | HTR3A 3049/4885HRH3 111/4885HRH4 12/4885 |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | PDE4B, PDE3B, PDE4A | HTR3A 2717/4885HRH3 3330/4885HRH4 2418/4885 |
| US-20130143870-A1 | NOVEL COMPOUNDS | GRM5, GRM1, GRIK5 | HTR3A 280/4885HRH3 408/4885HRH4 383/4885 |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, SQOR, TST | HTR3A 3049/4885HRH3 111/4885HRH4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.