Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CCR3 | P51677 | 14/20 | 0.39 |
| ▸ | HRH1 | P35367 | 13/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108889 | 0.92 | HRH1 (0.44) | HSD11B1CCR3HRH1KCNH2FFAR4 | |
| SCHEMBL1108890 | 0.91 | HSD11B1 (0.40) | HSD11B1CCR3HRH1KCNH2FFAR4 | |
| SCHEMBL1108870 | 0.86 | HSD11B1 (0.41) | HSD11B1ACACB | |
| SCHEMBL1108873 | 0.85 | EPHX2 (0.41) | CCR3KCNH2 | |
| SCHEMBL1108875 | 0.84 | SCN1A (0.40) | HSD11B1 | |
| SCHEMBL1108888 | 0.84 | HSD11B1 (0.41) | HSD11B1CCR3HRH1KCNH2FFAR4 | |
| SCHEMBL1108860 | 0.82 | HSD11B1 (0.57) | HSD11B1 | |
| SCHEMBL1108869 | 0.81 | SRD5A1 (0.47) | HSD11B1CCR3HRH1KCNH2ACACB | |
| SCHEMBL1108871 | 0.81 | OPRK1 (0.43) | HSD11B1CCR3HRH1KCNH2 | |
| SCHEMBL1108881 | 0.80 | SCN9A (0.48) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-7683059-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683059-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | AMGEN SF LLC | 2008-10-09 | — | — | US | disclosed |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | AMGEN SF LLC | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | HSD11B1, HSD17B1, HSD17B3 | HSD11B1 1/4885CCR3 1882/4885HRH1 3796/4885 |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | GPR119, CYP11B2, CYP11B1 | HSD11B1 41/4885CCR3 2071/4885HRH1 3627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.