Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089778 | 0.81 | SMN1; SMN2 (0.53) | RAB9ANPC1KCNH2SCN5ASCN9A | |
| SCHEMBL11080475 | 0.81 | MEN1 (0.53) | RAB9ANPC1KCNH2SCN5ASCN9A | |
| SCHEMBL17403482 | 0.81 | MAPT (0.52) | RAB9ANPC1SMN1; SMN2HTTCYP1A2 | |
| SCHEMBL19075472 | 0.79 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2TUBB4ATUBB | |
| SCHEMBL12253181 | 0.75 | NPC1 (0.61) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL11078558 | 0.74 | POLA1 (0.50) | LMNATDO2NPY5RMAPK1 | |
| SCHEMBL11089031 | 0.73 | HTT (0.57) | RAB9ANPC1SMN1; SMN2HTTLMNA | |
| SCHEMBL10938637 | 0.73 | TUBB4A (0.58) | RAB9ANPC1JAK2KCNH2SCN5A | |
| SCHEMBL16014242 | 0.70 | MAPT (0.44) | GAAMAPTMEN1KMT2A | |
| SCHEMBL20355151 | 0.70 | RAB9A (0.67) | RAB9ANPC1JAK2KCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | claimed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | claimed |
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |