Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 7/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11093127 | 0.99 | MEN1 (0.34) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL11087533 | 0.78 | ALDH1A1 (0.37) | CYP3A4CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL11092419 | 0.77 | ALDH1A1 (0.41) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL11260058 | 0.77 | KCNA5 (0.43) | ALDH1A1MAPTHSD17B10LMNAKDM4E | |
| SCHEMBL11759149 | 0.62 | KIF11 (0.41) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL5438992 | 0.62 | SMN1; SMN2 (0.40) | CYP3A4CYP2D6MEN1KMT2AALDH1A1 | |
| SCHEMBL20126694 | 0.62 | ALDH1A1 (0.55) | CYP3A4CYP2C19ALDH1A1MAPTMAPK1 | |
| SCHEMBL15546036 | 0.60 | CYP2B6 (0.43) | CYP3A4ALDH1A1CYP19A1 | |
| SCHEMBL11262738 | 0.60 | KMT2A (0.50) | CYP3A4CYP2D6CYP2C19KMT2AALDH1A1 | |
| SCHEMBL11821438 | 0.59 | ESRRB (0.36) | CYP2C19KMT2AALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486431-A | Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1984-12-04 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |