Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1103985 | 0.85 | GPR119 (0.42) | GRM5GRIN2BLNPEPCYP2D6CYP2C9 | |
| SCHEMBL31198740 | 0.79 | GRM5 (0.52) | GRM5GRIN2BLNPEPPRMT1SMN1; SMN2 | |
| SCHEMBL13490670 | 0.76 | GRM5 (0.52) | GRM5GRIN2BLNPEPCYP2D6CYP2C9 | |
| SCHEMBL13490526 | 0.76 | GRM5 (0.53) | GRM5GRIN2BLNPEPCYP3A4PRMT1 | |
| SCHEMBL30365847 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPCYP3A4PRMT1 | |
| SCHEMBL171485 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPPRMT1SMN1; SMN2 | |
| SCHEMBL171369 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPPRMT1SMN1; SMN2 | |
| SCHEMBL13490532 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPCYP2D6CYP2C9 | |
| SCHEMBL1577496 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPPRMT1SMN1; SMN2 | |
| SCHEMBL30899650 | 0.75 | GRM5 (0.52) | GRM5GRIN2BLNPEPCYP3A4PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258156-B2 | Compounds and compositions as modulators of GPR119 activity | IRM LLC (BM) | 2012-09-04 | — | — | US | disclosed |
| US-8153635-B2 | Compounds and compositions as modulators of GPR119 activity | IRM LLC (BM) | 2012-04-10 | — | — | US | disclosed |
| US-20110224185-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC, a Delaware Limited Company (BM) | 2011-09-15 | — | — | US | disclosed |
| US-20090270409-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224185-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | GPR119, GPR65, GPR39 | GRM5 88/4885GRIN2B 275/4885LNPEP 3350/4885 |
| US-20090270409-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | GPR119, GPR65, GPR39 | GRM5 88/4885GRIN2B 275/4885LNPEP 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.