Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13654942 | 0.93 | CHRM3 (0.42) | L3MBTL1NPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL404609 | 0.93 | CHRM3 (0.42) | L3MBTL1NPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL10285902 | 0.87 | L3MBTL1 (0.41) | L3MBTL1NPC1TPSAB1TPSD1TPSG1 | |
| SCHEMBL13659485 | 0.86 | ALDH1A1 (0.41) | DRD2DRD4L3MBTL1NPC1RAB9A | |
| SCHEMBL1109460 | 0.86 | ALDH1A1 (0.41) | DRD2DRD4L3MBTL1NPC1RAB9A | |
| SCHEMBL1912207 | 0.86 | ALDH1A1 (0.41) | DRD2DRD4L3MBTL1NPC1RAB9A | |
| SCHEMBL10285921 | 0.86 | DRD2 (0.57) | DRD2DRD4MCHR1CHRM1CYP2D6 | |
| SCHEMBL1912230 | 0.86 | DRD2 (0.57) | DRD2DRD4MCHR1CHRM1CYP2D6 | |
| SCHEMBL1912172 | 0.85 | MCHR1 (0.48) | L3MBTL1TPSAB1TPSD1TPSG1MCHR1 | |
| SCHEMBL1912174 | 0.83 | SMYD3 (0.58) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153843-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2012-04-10 | — | — | US | disclosed |
| US-8101640-B2 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8084615-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2011-12-27 | — | — | US | disclosed |
| US-7989660-B2 | BACTERICIDE AGAINST GRAMNEGATIVE BACTERIA; RESPIARATORY SYSTEM DISORDERS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20110172174-A1 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS INC. | 2011-07-14 | — | — | US | disclosed |
| US-20100324025-A1 | Antibacterial Agents | UNIVERSITY OF WASHINGTON (US) | 2010-12-23 | — | — | US | disclosed |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | UNIVERSITY OF WASHINGTON (US) | 2009-06-25 | — | — | US | disclosed |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2008-10-30 | — | — | US | disclosed |
| US-20070244197-A1 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244197-A1 | Antibacterial agents | MRPL21, SI, PGLS | DRD2 3836/4885DRD4 2755/4885L3MBTL1 2665/4885 |
| US-20110172174-A1 | Antibacterial agents | MRPL21, SI, PGLS | DRD2 3836/4885DRD4 2755/4885L3MBTL1 2665/4885 |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | DRD2 3836/4885DRD4 2755/4885L3MBTL1 2665/4885 |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | DRD2 3836/4885DRD4 2755/4885L3MBTL1 2665/4885 |
| US-20100324025-A1 | Antibacterial Agents | MRPL21, SI, PGLS | DRD2 3836/4885DRD4 2755/4885L3MBTL1 2665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.