Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | RB1 | P06400 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849713 | 0.88 | PKM (0.46) | MAP2K4MAP2K7PKMKMT2ATDP1 | |
| SCHEMBL5849863 | 0.88 | ALDH1A1 (0.53) | PKMKMT2AKDM4ERECQLSMN1; SMN2 | |
| SCHEMBL5848834 | 0.81 | PKM (0.42) | MAP2K4MAP2K7PKMKMT2ATDP1 | |
| SCHEMBL5848446 | 0.81 | MAPK1 (0.42) | MAP2K4MAP2K7PKMKMT2ATDP1 | |
| SCHEMBL5848008 | 0.81 | LMNA (0.44) | PKMKDM4ERECQLSMN1; SMN2HTR1A | |
| SCHEMBL5849861 | 0.79 | ALDH1A1 (0.46) | PKMKMT2ASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL2372170 | 0.78 | SMN1; SMN2 (0.68) | MAP2K4MAP2K7UCHL1KMT2ATDP1 | |
| SCHEMBL5849888 | 0.76 | MMP1 (0.41) | PKMKMT2ATDP1KDM4ERECQL | |
| SCHEMBL11083302 | 0.74 | PTGS1 (0.57) | KMT2APTGS1PTGS2 | |
| SCHEMBL11091670 | 0.74 | PTGS1 (0.57) | KMT2APTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112605-B2 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences (CN) | 2006-09-26 | — | — | US | claimed |