Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095919 | 0.87 | KMT2A (0.44) | L3MBTL1KMT2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL11094010 | 0.86 | KMT2A (0.43) | KDM4EL3MBTL1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL11090280 | 0.85 | KMT2A (0.43) | L3MBTL1KMT2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL11088418 | 0.85 | CYP3A4 (0.47) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11131374 | 0.85 | MAPT (0.47) | MAPTKDM4EL3MBTL1CRHBPCRHR2 | |
| SCHEMBL11390128 | 0.85 | ALOX15 (0.47) | KMT2AALDH1A1GAA | |
| SCHEMBL11093116 | 0.85 | ALDH1A1 (0.43) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11082845 | 0.84 | KMT2A (0.41) | MAPTKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL11090241 | 0.80 | KMT2A (0.44) | MAPTKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL11092807 | 0.79 | LTA4H (0.47) | L3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486443-A | PROSTAGLANDIN-LIKE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1984-12-04 | — | — | US | disclosed |
| US-4262128-A | HAVING PROSTAGLANDIN-LIKE BIOLOGICAL PROPERTIES | BURROUGHS WELLCOME CO. (US) | 1981-04-14 | — | — | US | disclosed |