Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 known ✓ | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG known ✓ | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 known ✓ | P11230 | 1/20 | 0.38 |
| ▸ | CHRND known ✓ | Q07001 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922847 | 0.98 | OPRL1 (0.47) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| Ethylene SCHEMBL11096905 | 0.95 | OPRL1 (0.45) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL11074012 | 0.81 | OPRM1 (0.43) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL11095398 | 0.81 | SLC6A3 (0.47) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL517439 | 0.81 | OPRL1 (0.50) | OPRL1OPRM1OPRK1SLC6A2SLC6A3 | |
| SCHEMBL9729492 | 0.80 | MEN1 (0.60) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL517752 | 0.79 | OPRL1 (0.69) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| Ethylene SCHEMBL10832290 | 0.78 | OPRD1 (0.41) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| Cyclopropane SCHEMBL11098599 | 0.78 | OPRM1 (0.42) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL30404322 | 0.78 | OPRM1 (0.50) | OPRL1OPRM1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |