Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19535638 | 0.87 | MEN1 (0.53) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL19094274 | 0.84 | OPRM1 (0.50) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL3413521 | 0.83 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL11078629 | 0.82 | OPRL1 (0.51) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL11094654 | 0.82 | MEN1 (0.52) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL4014546 | 0.81 | OPRM1 (0.46) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL517788 | 0.81 | OPRM1 (0.44) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL4022665 | 0.81 | OPRM1 (0.44) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| Hydrochloric Acid SCHEMBL11096937 | 0.80 | MEN1 (0.50) | OPRL1OPRM1OPRK1MEN1CYP2C9 | |
| SCHEMBL3922847 | 0.80 | OPRL1 (0.47) | OPRL1OPRM1OPRK1MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 335 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797924-B1 | SOLID FORMS OF (1R,4R)-6'-FLUORO-(N,N-DIMETHYL)-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO-[CYCLOHEXANE-1,1'-PYRANO-[3,4,B]INDOL]-4-AMINE AND SULFURIC ACID | GRUENENTHAL GMBH (DE) | 2016-06-01 | — | — | EP | claimed |
| US-8912343-B2 | Solid forms of (1r,4r)-6′-fluoro-(N, N-dimethyl)-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and sulfuric acid | GRUENENTHAL GMBH (DE) | 2014-12-16 | — | — | US | claimed |
| EP-2797924-A1 | SOLID FORMS OF (1R,4R)-6'-FLUORO-(N,N-DIMETHYL)-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO-[CYCLOHEXANE-1,1'-PYRANO-[3,4,B]INDOL]-4-AMINE AND SULFURIC ACID | Grünenthal GmbH (DE) | 2014-11-05 | — | — | EP | claimed |
| US-8614245-B2 | Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine | GRUENENTHAL GMBH (DE) | 2013-12-24 | — | — | US | claimed |
| WO-2013087591-A1 | SOLID FORMS OF (1R,4R)-6'-FLUORO-(N,N-DIMETHYL)-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO-[CYCLOHEXANE-1,1'-PYRANO-[3,4,B]INDOL]-4-AMINE AND SULFURIC ACID | Grünenthal GmbH (DE) | 2013-06-20 | — | — | WO | claimed |
| US-20130150589-A1 | Solid forms of (1 r,4r)-6' -fluoro-(N, N-dimethyl)-4-phenyl-4' ,9'-dihydro-3'H-spiro[ cyclohexane-1,1 '-pyrano-[3,4,b]indol]-4-amine and sulfuric acid | GRUENENTHAL GMBH (DE) | 2013-06-13 | — | — | US | claimed |
| US-20130123324-A1 | Crystalline (1r, 4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine | GRUENENTHAL GMBH (DE) | 2013-05-16 | — | — | US | claimed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | claimed |
| EP-4665333-A1 | REGIMENS AND COMPOSITIONS USEFUL FOR ALLEVIATING PAIN | Adneuris Therapeutics, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |
| EP-4633628-A1 | REGIMENS AND COMPOSITIONS USEFUL FOR ALLEVIATING PAIN | Adneuris Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| WO-2024173714-A1 | REGIMENS AND COMPOSITIONS USEFUL FOR ALLEVIATING PAIN | PARK THERAPEUTICS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |
| WO-2024129782-A1 | REGIMENS AND COMPOSITIONS USEFUL FOR ALLEVIATING PAIN | PARK THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| WO-2002090317-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123324-A1 | Crystalline (1r, 4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine | HTR1D, HTR4, HTR1B | OPRL1 1779/4885OPRM1 362/4885OPRK1 663/4885 |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | OPRL1 3/4885OPRM1 5/4885OPRK1 1/4885 |
| US-20130150589-A1 | Solid forms of (1 r,4r)-6' -fluoro-(N, N-dimethyl)-4-phenyl-4' ,9'-dihydro-3'H-spiro[ cyclohexane-1,1 '-pyrano-[3,4,b]indol]-4-amine and sulfuric acid | CYP2S1, SULT1E1, SULT2A1 | OPRL1 1107/4885OPRM1 234/4885OPRK1 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.