Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219522 | 0.87 | PKM (0.76) | PKMHTTEPHX1ALDH1A1GAA | |
| SCHEMBL11877777 | 0.85 | HTT (0.70) | PKMHTTEPHX1ALDH1A1GAA | |
| SCHEMBL11049847 | 0.83 | PKM (0.60) | PKMHTTEPHX1ALDH1A1GAA | |
| SCHEMBL11263800 | 0.83 | HTT (0.59) | HTTALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL11252215 | 0.82 | RORC (0.46) | PKMHTTALDH1A1KMT2AMAPT | |
| SCHEMBL11579516 | 0.81 | MAPT (0.50) | HTTALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL11580960 | 0.81 | GAA (0.53) | PKMALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL11580880 | 0.81 | F10 (0.43) | PKMHTTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4107529 | 0.81 | HTT (0.56) | HTTALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL11579736 | 0.81 | MAPT (0.53) | PKMHTTALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |