Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880298 | 0.84 | MAPT (0.52) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11580960 | 0.84 | GAA (0.53) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11579736 | 0.84 | MAPT (0.53) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11580880 | 0.84 | F10 (0.43) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11263800 | 0.84 | HTT (0.59) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11580082 | 0.83 | ALDH1A1 (0.51) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11252215 | 0.83 | RORC (0.46) | MAPTKMT2AHTTALDH1A1RAB9A | |
| SCHEMBL11050707 | 0.82 | KMT2A (0.52) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4107529 | 0.81 | HTT (0.56) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11093549 | 0.81 | PKM (0.66) | MAPTKMT2AMEN1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |