Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878484 | 0.86 | RORC (0.47) | RORCALDH1A1MAPTRAB9AHTT | |
| SCHEMBL11263800 | 0.85 | HTT (0.59) | ALDH1A1MAPTRAB9AHTTPOLB | |
| SCHEMBL11580960 | 0.83 | GAA (0.53) | ALDH1A1MAPTRAB9APKMPOLB | |
| SCHEMBL4107529 | 0.83 | HTT (0.56) | ALDH1A1MAPTHTTPOLBKMT2A | |
| SCHEMBL11580880 | 0.83 | F10 (0.43) | ALDH1A1MAPTRAB9AHTTPKM | |
| SCHEMBL11579736 | 0.83 | MAPT (0.53) | ALDH1A1MAPTRAB9AHTTPKM | |
| SCHEMBL11579516 | 0.83 | MAPT (0.50) | RORCALDH1A1MAPTRAB9AHTT | |
| SCHEMBL11054990 | 0.83 | TBXA2R (0.47) | RORCALDH1A1MAPTHTTPOLB | |
| SCHEMBL11093549 | 0.82 | PKM (0.66) | ALDH1A1MAPTHTTPKMKMT2A | |
| SCHEMBL30168169 | 0.80 | SMN1; SMN2 (0.59) | RORCALDH1A1MAPTHTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |