Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345653 | 0.89 | PARP1 (0.46) | PARP1KDM4ETET2TET1ALDH1A1 | |
| SCHEMBL7345844 | 0.80 | ALDH1A1 (0.55) | PARP1KDM4EPIM1ALDH1A1LMNA | |
| SCHEMBL7348155 | 0.76 | DAO (0.44) | PARP1KDM4EHTTTDP1DAO | |
| SCHEMBL16463537 | 0.76 | DAO (0.62) | PARP1KDM4EMAPTTDP1JAK2 | |
| SCHEMBL1210670 | 0.76 | DAO (0.62) | PARP1MAPTSMN1; SMN2RIPK1DAO | |
| SCHEMBL10964234 | 0.75 | CSNK2A1 (0.41) | PARP1KDM4EJAK2DAO | |
| SCHEMBL7339417 | 0.74 | PARP1 (0.47) | PARP1KDM4EALDH1A1SLC40A1LMNA | |
| SCHEMBL10811949 | 0.73 | KDM4E (0.56) | PARP1KDM4EALDH1A1TSHRHTT | |
| SCHEMBL7341890 | 0.72 | PARP1 (0.44) | PARP1KDM4ELMNAHSP90AA1CYP3A4 | |
| SCHEMBL7337387 | 0.71 | ALDH1A1 (0.51) | PARP1KDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |