Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095481 | 0.89 | PARP1 (0.54) | PARP1TET2TET1KDM4EMAPT | |
| SCHEMBL7337387 | 0.83 | ALDH1A1 (0.51) | PARP1KDM4EMAPTLMNAPMP22 | |
| SCHEMBL7339417 | 0.74 | PARP1 (0.47) | PARP1KDM4EMAPTLMNACYP3A4 | |
| SCHEMBL7349473 | 0.73 | ALDH1A1 (0.50) | PARP1KDM4EMAPTLMNAPMP22 | |
| SCHEMBL7341890 | 0.72 | PARP1 (0.44) | PARP1KDM4EMAPTLMNACYP3A4 | |
| SCHEMBL7345844 | 0.71 | ALDH1A1 (0.55) | PARP1KDM4EMAPTLMNATDP1 | |
| SCHEMBL15388981 | 0.70 | PARP1 (0.51) | PARP1TET2TET1KDM4EMAPT | |
| SCHEMBL13210000 | 0.68 | XDH (0.46) | KDM4EMAPTLMNATP53ALOX15 | |
| SCHEMBL14738901 | 0.68 | MAP2K1 (0.51) | KDM4EMAPTLMNACYP3A4TP53 | |
| SCHEMBL2442863 | 0.67 | PARP1 (0.69) | PARP1KDM4ETDP1DAOGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |