Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049490 | 0.84 | DCTPP1 (0.42) | CFTRMAPTAGTR1AGTR2PTGDR2 | |
| SCHEMBL11099111 | 0.82 | AR (0.52) | CFTRMAPTPTGDR2PLA2G2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11261373 | 0.80 | AGTR1 (0.42) | AGTR1AGTR2PTGDR2PLA2G2A | |
| SCHEMBL11166536 | 0.80 | PTGDR2 (0.49) | CFTRAGTR1AGTR2PTGDR2PLA2G2A | |
| SCHEMBL8954292 | 0.79 | ALDH1A1 (0.49) | AGTR1AGTR2PTGDR2ALDH1A1 | |
| SCHEMBL7902270 | 0.78 | AGTR1 (0.43) | AGTR1AGTR2PTGDR2 | |
| SCHEMBL11093449 | 0.75 | ALDH1A1 (0.48) | AGTR1AGTR2PLA2G2AALDH1A1 | |
| SCHEMBL29411951 | 0.75 | CFTR (0.72) | CFTRMAPTALDH1A1 | |
| SCHEMBL6227119 | 0.74 | ALDH1A1 (0.43) | AGTR1AGTR2PLA2G2AALDH1A1 | |
| SCHEMBL11090546 | 0.73 | ALDH1A1 (0.54) | AGTR1AGTR2PTGDR2ALDH1A1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028834-B1 | IMIDAZOLE-5-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-18 | — | — | EP | disclosed |
| US-4355040-A | Hypotensive imidazole-5-acetic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| EP-0028834-A1 | Imidazole-5-acetic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |