Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 19/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10607297 | 0.96 | FFAR2 (0.61) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL10606078 | 0.96 | FFAR2 (0.61) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL3880453 | 0.84 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL10614585 | 0.84 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL1780649 | 0.84 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL1677207 | 0.80 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL10757938 | 0.80 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL1405698 | 0.80 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A | |
| Potassium Ion SCHEMBL10803880 | 0.80 | BRD4 (0.47) | FFAR2MEN1LMNAKMT2A | |
| SCHEMBL27469442 | 0.80 | FFAR2 (0.65) | FFAR2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006354-B1 | FLUORO-SUBSTITUTED PYRETHROID-TYPE ESTERS, PROCESSES FOR THEIR PREPARATION, INTERMEDIATES FOR USE IN SUCH PROCESSES, COMPOSITIONS FOR INSECTICIDAL USE, AND METHODS OF COMBATING INSECT PESTS | ICI AUSTRALIA LIMITED (AU) | 1984-09-26 | — | — | EP | disclosed |
| US-4376784-A | Pesticidal fluorinated esters of the pyrethrin or pyrethroid type | ICI AUSTRALIA LIMITED (AU) | 1983-03-15 | — | — | US | disclosed |
| US-4283414-A | Pesticidal fluorinated esters of the pyrethrin or pyrethroid type | ICI AUSTRALIA LIMITED (AU) | 1981-08-11 | — | — | US | disclosed |
| EP-0006354-A1 | Fluoro-substituted pyrethroid-type esters, processes for their preparation, intermediates for use in such processes, compositions for insecticidal use, and methods of combating insect pests | ICI AUSTRALIA LIMITED (AU) | 1980-01-09 | — | — | EP | disclosed |